Posttranslational modifications of tissue factor

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Posttranslational modifications of tissue factor.

Tissue factor (TF), a membrane protein, is an initiator of blood coagulation in vivo. In this review we discuss how posttranslational modifications affect activity and other properties of TF. Glycosylation of the extracellular domain and the composition of carbohydrates at three glycosylation sites have an influence on TF activity in the extrinsic FXase by increasing the rate of FX proteolysis....

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ژورنال

عنوان ژورنال: Frontiers in Bioscience

سال: 2012

ISSN: 1945-0494,1945-0508

DOI: 10.2741/385